How Do I Know When to Take Acetaminophen Versus Ibuprofen?



Medications are not one size fits all, so NBC News medical contributor Dr. Akshay Syal joins TODAY to break down the best medicines for every ailment. He explains when to use acetaminophen versus ibuprofen, when to throw away old medicines, and more.

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21 Comments

  1. They are two totally different kinds of medications. Ibuprofen does nothing for tooth pain, but acetaminophen does. Back pain depends, most of the time Ibuprofen or naproxinn sodium is better for that as it is usually muscle pain so a nsaid is best.

  2. They both caused my kidneys and liver to shut down because Drs would not prescribe REAL pain meds for my broken spine and neck, so they prescribed ibuprofen 800 mg 4 times a day. My organs shut down and caused a heart attack. Now my Drs don’t want me taking ibuprofen or acetaminophen and prescribe tramadol for as needed. Which is 30 pills a month and no heart attack or organs shutting down. Be careful. Just because something is cheaper or over the counter does not mean it is safe. Ask your Drs about the dangers of ibuprofen and acetaminophen.

  3. You are not supposed to take neither for proper blood flow actually. Ibuprofen thins your blood. Acetaminophen thickens your blood. Ibuprofen is for inflammation and acetaminophen is for muscle pain. Aleve is for bone pain.

  4. Questions about choosing between OTC medications like ibuprofen and acetaminophen are exactly the kind of questions that pharmacists, with Doctor of Pharmacy (PharmD) training, are specifically trained to answer. A pharmacist would have been a great expert to include here to discuss patient-specific risks, drug interactions, and when one option may be safer than the other, especially since the choice is not simply “trial and error.” Factors such as pregnancy, kidney/GI risk, other medications, and the type of pain all matter. NSAIDs like ibuprofen should generally be avoided starting at 20 weeks of pregnancy unless specifically recommended by a healthcare professional, while for acute dental pain, current ADA guidance actually recommends NSAIDs alone or with acetaminophen as first-line therapy when appropriate. I’d also be cautious about telling viewers that expired medications are “generally safe.” After the expiration date, their safety, quality, potency, and effectiveness are no longer guaranteed, which is why the FDA recommends not using expired medications. Pharmacists are the medication experts, not medical doctors.

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