Dr. Dominic D’Agostino is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology.
Dom is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.
His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.
Today, we are talking all about the prevention and treatment of cancer using metabolic therapies.
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In this episode, we discuss:
00:00 – Intro
00:22 – Why the ketogenic diet is a therapeutic way to treat & prevent cancer
02:43 – What does cancer as a metabolic disease mean?
08:24 – The prescription-strength ketogenic diet
15:59 – The ketogenic diet and latest cancer research
22:08 – Tumors and metastatic cancer
28:47 – The two fuels that feed cancer
32:05 – What glucose ketone index (GKI) ratio is therapeutic for cancer?
38:23 – Understanding blood glucose range
42:38 – The ketogenic diet combined with radiation
47:24 – The problem with chemotherapy
51:07 – Supplements to help manage blood glucose
54:18 – Supplement recommendations for cancer treatment & prevention
1:04:17 – What is the therapeutic benefit of ketones?
1:13:56 – Carbs and ketones
1:19:04 – The carnivore diet & cancer
1:24:37 – Dom’s thoughts on a plant-based approach to cancer
1:29:37 – Water fasting before chemotherapy
1:35:03 – Hyperbaric oxygen therapy is beneficial for radiation necrosis
1:40:27 – How to lower glutamine naturally?
1:45:10 – Glutamine and cancer
1:50:07 – Exercise is an important component of cancer treatment
1:53:11 – An integrative approach to cancer
Show notes:
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Disclaimer
The opinions expressed in this video are those of the guest and are presented for informational purposes only. This content is not medical advice. Please consult your healthcare provider regarding any health-related decisions.
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Thank you for watching this episode with Dr. Dominic D'Agostino! If you're finding it valuable, please vote by hitting the LIKE button on the video. This lets me know what type of guests to book for upcoming shows. Thanks! -Jesse 💙
To gdzie szukac TAKIEGO ONKOLOGA…????
Im 51 and have had cancer since 2016. Im in remission because of metabolic protocols. STG4 mets in 2023. I quit chemo and immunotherapy in april 2024 when stable but not shrinking. A year later I did the press pulse metabolic protocol and was in remission by july 2025. No evidence of disease. Ill share my story. Ill share my scans. Everyone needs to try this BEFORE oncologys dogma gets ya.
Super koment vášho hosťa aj vás. Prajem vám obom veľa zdravia a úspechov v práci. Ďakujem ❤❤ Mária
Sono. Diabetica. Ma. Mangio. Alimenti. Che. Non. Nutrono. Il. Cancro. Preferisco. La. Cucina. Cinese.
Wow !!!!!! Buenísima información, soy médico de familia
Seit wann ist Bauchspeichel Drüsenkrebs heilbar ???
Hola quienes son aptos para la Dieta Citogenica???? Quiero saber si yo sería candidata???
bj
désole ,les médecins ne savent rien
Finally, thank you Dr Dominic for helping to get the word out that cancer is a medabolic diseace. This was a very informative podcast, you just saved some lives if people listening follow your and Dr Seyfrieds advice, thank you once again.
ottimo video anche se, per la stragrande maggioranza della comunità scientifica e oncologica internazionale, il cancro non è considerato principalmente una patologia metabolica, bensì una malattia genetica e molecolare delle cellule.
Esiste tuttavia un dibattito molto attivo e alcune correnti minoritarie che spingono per una rilettura metabolica.
What role do long-term serious life problems, which intensify before the onset of illness, play? Are there any experiences with this? And do the affected people also satisfy their emotional needs through eating and little exercise?
Thymoma can srink with diet?
I was looking forward to listening to Dr D’Agostino and your interview but I have to say that it was far beyond most laymen understanding. This was chocked full of a pretty dense medical jargon and over the head of most layman interest in Keto and Cancer treatment.
Summary – Dr. Dominic D'Agostino discusses cancer as a metabolic disease and explains how therapeutic and prescription-strength ketogenic diets can be utilized alongside standard medical care to starve cancer cells, improve metabolic health, and enhance treatment outcomes.
Cancer as a Metabolic Disease:
While mainstream medicine views cancer primarily through genetic mutations, Dr. D'Agostino emphasizes that nuclear genome instability is intimately linked to impaired mitochondrial bioenergetics and energy crises. Many cancer cells heavily rely on glucose and fermentation for growth (the Warburg effect).
The Role of the Ketogenic Diet:
Eating a well-formulated ketogenic diet (high in healthy fats, moderate in quality protein, low in carbohydrates) lowers blood glucose and elevates ketones, effectively depriving glycolytic cancer cells of their preferred fuel source.
Dr. D'Agostino highlights the Glucose Ketone Index (GKI)—maintaining a calculated ratio between 1 to 3—as a therapeutic benchmark for achieving tumor-suppressive and neuroprotective benefits.
Synergy with Standard Care & Drugs:
Rather than viewing it as a standalone alternative, he advocates for an integrative approach. The ketogenic diet suppresses insulin surges, which can otherwise counteract certain targeted cancer drugs (such as PI3K inhibitors) or fuel tumor progression.
Focus on Aggressive Cancers:
Research and clinical trials have increasingly targeted aggressive or difficult-to-treat conditions like glioblastoma (brain tumors) and metastatic cancers, where conventional treatments alone often have limited success.
There are no trials of drugs for adeno cystic carcinoma & no treatment available from regular cancer docs.
Vamos traduzir para o português por favor
Wonderful interview, so informative. Thank you. 🙏🏽
Oil free plant based Whole Foods can heal as well. Lots of green leafy
Cuando el cáncer es incuestionable en personas aparentemente saludables, vemos que es algo más allá de solo una enfermedad metabolica, pero los médicos no lo quieren abordar por ser algo "no comprobable" o "místico"… Pero es real, los sentimientos o resentimientos emocionales, tienen mucho que ver…
Hay 4 que influyen directamente en la producción de cáncer…
El miedo, la culpa, la vergüenza, el odio…
A nivel atemporal y de alta magnitud, contribuyen en el cáncer, y me consta.
Thanks ❤❤❤
Muito bom saber, A dieta cetogênica.
Jessé cadê tradução em português. Obrigada 😃😊
Traduzir
Would love to see truth calkins on the podcast!
I bumped into your videos recently and became an addict. Great interviews. Lost 2 friends recently from cancer and how l wish we had an opportunity to try this alternative therapy. Regards frm Kenya
Fantastic interview Jesse with Dr Dom.. I appreciate the conversation and the questions you asked. 😄👍👏👏
Interesting interview but too long .
Like you said, Jesse, GREAT RESOURCE!! 👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍
Ich bin ein Krebspatient und bei mir nur die keto-Diät nie funktioniert langfristig.Ich hab ziemlich schnell Gallen und Leber Probleme auftreten habe.Low-carb Diät oder gemischte Diät Keto/low-carb besser funktioniert habe.Eine Tag low-carb das andere Tag keto oder Mediterran Diät.Oder erste Mahlzeit low-carb die zweite Mahlzeit Keto die dritte Mahlzeit wider Low-Carb.Nächsten Tag umgekehrt.3-4 pro Woche Training in Fitnessstudio 1,5-2 stunden.Anaerob Training und Aerob Training.Alles in Badezimmern ausgetauscht habe.Nur Natur Produkte (Duschgel,Seife,Zahnpasta).Ich trinke nur Wasser mit niedrigen mpp wert.Niedrigen mpp wert heißt unter 20mpp.Versuche ich immer mehr spazieren im Wald mit meine Hunden.Keine stress!!Sehr wichtig keine stress.Wenn deine Frau nervt muss Dich trennen,wenn dein Chef oder dein Arbeit Stress macht muss aufhören.Positive Denkart und immer kurzfristige oder sogar langfristige planen machen was um deine Zukunft geht.😊
How tumor gets oxygenated? Dr Seyfried told that tumor doesn't take oxygen for survival.
Does fasting mimicking diet works
Good questions, good answers, good job!