Parkinson’s disease is the second most common neurodegenerative disease behind Alzheimer’s disease. What is its pathophysiology? What are the pharmacological strategies towards treatment? Let’s find out!
Script by Michael Keith
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Great video!! Would love to see you dive into other neurological conditions including adhd asd and hopefully FND🙏🏼
Dopamine also diffuses by volume transmission, and by reuptake, can resupply the damaged neuron.
When you cover amphetamine, read the Wikipedia article. Normally a risky idea, this article is exceptional.
it's tragic how stigmatized alzheimer's is to a point where people aren't even remotely aware of other neurodegenerative diseases. thank you for making this.
Small correction at 8:28: L-DOPA crosses the blood–brain barrier because it's a substrate for an amino acid transporter called LAT1, not because it is more lipophilic than dopamine. If you compare their LogP, L-DOPA (-2.4) is much more polar/less lipophilic than dopamine (-1). Also L-DOPA can better survive peripheral metabolism to achieve therapeutically useful plasma concentrations, particularly with carbidopa, whereas dopamine undergoes extensive first-pass inactivation.
I can't wait for the talk about drug addiction. I always found the pathophysiology of substance dependence quite fascinating.
Somthing to look forward to for me likely. To take it with a laugh. Best laughs, making ones sufering bearable treating it like a tragycomedy. Tears are for others. Like my persecuters with their sad sick laughs. Also funny like some rl evil gnomes.
Insightful
Do evangelists suffer from this?
Thank you Dave. I appreciate your dedication with these informative and concise tutorials. ❤
Thank you, we hope to understand idiopathic Parkinson’s better to prevent it in the future. It appears to involve environmental agents and peripheral immune system infiltration of the brain. I dedicated my life to neuroscience research when my mother was diagnosed with early onset Parkinson’s.
Please please please do a video on Epilepsy if you plan on going after more neurological disorders. It’s really something that isn’t talked about enough and is heavily stigmatized in society…
I wonder if it would be worth doing a video about cerebral palsy in honor of RJ Mitte.
Old man Parkinsons, friends,
Al ziemers & Arthur Itis.
Parkinsons is notable for being one of the first neurological disorders for the FDA approved a non-pharmacological, technological treatment for reducing the symptoms of parkinsons: Deep Brain Stimulation.
Looking forward to you returning to this if / when you do a neurology series.
4:28 I have a question. If the result of both the direct and indirect pathway is the same (stimulation of the thalamus), then why is there 2 pathways instead of just 1?
I am sure these videos don't do as well as your debunking and scicom drama videos, but I appreciate you still making them as I enjoy them.
Science is amazing!!!! It's good to get these videos in between the ones calling out all the grifters and A-hole's misinformation that leads to deaths.
oh my god are you doing a neurology series? please please please i love neuropathology
Thank you for covering this. I reckon poor diet, lack of exercise, chronic stress and substance abuse can all be major factors. I've seen it first-hand.
My grandfather died 😢 bcz of this
my dad has this. thanks for educating folks about it.
The most famous person I know of who had Parkinson's disease is Micheal J. Fox, I was so sad that it basically ended his career as an actor. Back to the Future wouldn't be the same without him, IMO
I just read The Brain In Search of Itself about the scientist who discovered the neuron.
Its really a miniature electrical field, it really makes me wonder if there's more to electric stimulation the hamfisted gov tried years ago. With better tech,I think the cure uktimateky lies w electromagnectic therapy.
Thank you sir
With the amount of drugs i have used in the past 10 years i am 100% either going to get alzheimer or parkinson maybe even both together. I hope elon musks neurolink will improve in time for me to not make it a problem in my life. I think i have at least 20 or 25 years till the first symptoms to show. I am now still active in the weekends with 24/48 hours bender🥦🧪🧟♂️
Neurodegenerative diseases scare the bejeezuz out of me. The body is gonna wear out regardless, but as long as I am still okay upstairs I can figure out ways to cope. There is a point where you could be so far gone, you don't know you would rather be dead.
I was wondering if you could look at Dystonia. It's something I've struggled with my entire life so far, and I would love to learn more about how it affects the brain.
FINALLLLLY Neuroscience
Going to have to watch this a few more times and do a bit of reading to fully understand, but thanks for the info.
you cant sell me the future if you put a feather in its cap
2:07 Correct me if I am wrong but wasn't this in the futurama episode where fry ate that gas station sandwich and got super worms 😂😂😂
Curious about how it interplays with ADHD
thanks, my grandma has it and its nice to understand it better!
Just wanted to say hi, professor Dave/people, love yall, sending peace love and happiness Youre way❤
This is a horrible disease!!!
my mom was diagnosed with parkinsons about 2 years ago. She's doing well and its progressing slowly but it's still hard to see. We think her first symptoms were over 10 years ago but it was easy to ignore or miss at first.
hot damn I really wanna ratio someone with this
Hello MISTER FARINAHHH!
I wasn’t sure at first, but this is actually awesome
horrifying neurological disorder almost as bad as whatever destiny is going through
2 mins ago is spine tingling
❤❤❤
First?